This case study explains how MEASURE Evaluation and Pact Worldwide adapted a data demand and use (DDU) intervention to build a culture of data use within their organization and their partner organizations in Lesotho. The goal of the collaboration was to institutionalize DDU tools, curricula, and strategies in Pact’s institutional guidance and official structure in order to create a culture of data use in Lesotho and worldwide. The Lesotho program works to support local NGOs to respond better to the HIV/AIDS epidemic through orphan and vulnerable children (OVC) and HIV prevention programs.